SCN2A and autism: In this largest publicly available database of clinical data in patients with SCN2A variants (https://www.sfari.org/funded-project/simons-variation-in-individuals-project-simons-vip/), 10 individuals had an SCN2A variant and ADI-R data — 7 who were classified as having autism from the Autism Diagnostic Observation Schedule (ADOS; ref. 27), 2 who were classified as nonspectrum, and 1 with missing data.