Additionally, genes essential for synaptic function (Homer1, Homer2, and Bin1), were significantly up-regulated in both excitatory and inhibitory neurons of J20;GKO mice, suggesting that GSAP depletion may protect synaptic impairment in AD (De Rossi et al., 2020; Shiraishi-Yamaguchi and Furuichi, 2007). This evidence concerns the gene HOMER2 and Alzheimer disease.