Kiyuna et al. [15] demonstrated that osteosarcoma cells promoted angiogenesis in a Nestin-driven green fluorescent protein nude mouse model, and Zhang et al. [16] reported that tetrahydrocurcumin reduced osteosarcoma cell growth by suppressing angiogenesis, suggesting that angiogenesis could be an important treatment target in osteosarcoma. Here, NES is linked to osteosarcoma.