Therefore, we measured the expression of ICAM‐1 in the context of AIM2 deletion and found that both MCAO and OGD/R increased ICAM‐1 expression, whereas inhibiting AIM2 reversed these effects, suggesting that AIM2 deletion prevents ischemia‐induced BBB injury by downregulating ICAM‐1 expression. This evidence concerns the gene AIM2 and ischemia.