Finally, canities-affected white HFs also showed upregulation of antioxidant proteins, specifically those localized to mitochondria and cytoplasm (superoxide dismutase 1, SOD1; peroxiredoxin 2, PRDX2), in line with the role of oxidative stress in HS depigmentation (Arck et al., 2006; Wood et al., 2009). The gene discussed is SOD1; the disease is Hand-foot syndrome.