TNF and Multiple Organ Failure: 2017). Inhibition of TNF-α overproduction was proven to mitigate multiple organ failure and improve the survival of mice with endotoxemia (Penalva et al. 2017). Of the organs affected, the lungs are the most susceptible to failure. The prominent features of LPS-induced lung injury include neutrophil infiltration and oedema (Lingaraju et al. 2015). LPS induction results in the marked thickening of the alveolar wall, attributed to the influx of inflammatory cells (Huang et al. 2015).