In this context, the trend of decreased DNA damage,lipid peroxidation, intracellular ROS production withconcomitant improved motility in the 60% HF, 45%HF-AGEs and 60% HG-AGEs diets compared to the45% HF diet, suggest that an adaptation is taken placefollowing the increased levels of glucose and insulin,which probably activated a detoxification mechanism orthe glyoxalase pathway as an anti-glycation defense in thetestes and epididymis. The gene discussed is INS; the disease is hydrops fetalis.