In a study performed toevaluate expression of the specific genes, including AKAP, PRM2 andDAZ, it was showed that presence of DAZ andPRM2 genes can be used as a noninvasive molecular marker in seminal fluidof non-obstructive azoospermia patients to predict the presence or absence of sperm ormature spermatids (5). This evidence concerns the gene PRM2 and Azoospermia.