To this aim, a literature search was conducted on September 2020 using the PubMed‐NCBI database and the following search terms: (1) “phosphodiesterase*” OR “PDE” AND “Huntington” OR “Parkinson*” OR “movement disorder” OR “basal ganglia” OR “striatum”; and (2) “phosphodiesterase*” OR “PDE” AND “gene mutation.” Only articles written in English were considered, and the bibliographies of the retrieved articles and of relevant review articles were also checked. Here, ALDH7A1 is linked to movement disorder.