Over the years, mounting evidence has suggested that alterations in PDE expression, and consequently of cyclic nucleotides levels and their downstream targets, might occur with aging and in different age‐related diseases, including Alzheimer's disease,1, 4 and more recently their implication also has been suggested for several movement disorders, including, but not limited to, Huntington's disease (HD)5 and Parkinson's disease (PD).6 This evidence concerns the gene ALDH7A1 and Huntington disease.