PDE10A mRNA and protein levels decline in the striatum of R6/1 and R6/2 HD mice before onset of motor symptomsThe rate of reduction in PDE10A mRNA and protein is more rapid in R6/2 compared with R6/1 miceStriatal PDE1B mRNA levels decline in R6/1 and R6/2 HD mice, but to a lesser extent than PDE10APDE4A mRNA levels are relatively low in the striatum and do not differ between age‐matched WT and transgenic HD mice. The gene discussed is PDE10A; the disease is Huntington disease.