PDE10A and Huntington disease: PDE10A availability was decreased in striatum and pallidum and increased in motor thalamic nuclei in subjects with HD as compared with healthy control subjectsConnectivity‐based analysis revealed PDE10A decreases confined in the sensorimotor‐striatum and in striatonigral and striatopallidal projecting segmentsThe ratio between PDE10A expression in motor thalamic nuclei and in striatopallidal projecting striatum was the strongest correlate of higher probability of symptomatic conversion