PDE10A and Parkinson disease: A reduction of PDE10A activity also has been demonstrated in vivo in patients with PD: decreased striatal and pallidal binding of 11C‐IMA107 (ie, a highly selective PDE10A radioligand) was found in both patients with early and patients with more advanced PD, which correlated with the duration of the disease, as well as the severity of both motor symptoms and motor complications.63, 64