CEP290 and Kidney Cyst: Maternal zygotic (MZ) cep290fb208/fb208 mutants (hereafter referred to as MZcep290−/−) did not exhibit kidney cysts, otolith or left-right asymmetry defects (Fig. S1D), in accordance with previous reports from the zebrafish cep290 fh297 line (Lessieur et al., 2019).