CEP290 and Kidney Cyst: Acute deficiency in cep290 with morpholino injection produced canonical zebrafish ciliopathy phenotypes (Fig. 1C), such as body curvature, kidney cysts, otolith defects and left-right asymmetry, consistent with previous reports (Fig. S1A-D) (Baye et al., 2011; Sayer et al., 2006; Schäfer et al., 2008).