Before the initial TACE, the mean tumor size of R-HCC patients was significantly smaller than that of the TN-HCC patients (P<0.001), and there were significant differences in BCLC stage, Child-Pugh class, alanine transaminase, and aspartate aminotransferase between the two groups (P<0.05). In addition, there was no significant difference in the other baseline characteristics between the two groups. The gene discussed is GPT; the disease is hepatocellular carcinoma.