The pathophysiology ofnonspecific central nervous system symptoms, like headache and encephalopathy, mayrelate to neurotropic spread of the virus via the angiotensin converting enzyme 2(ACE2) receptor leading to a proinflammatory cascade and cytokine activation.5 This hyperinflammatory state has been associated with steroid responsiveencephalopathy and negative imaging findings.30 Additional factors include hypoxia, metabolic derangements, and medicationsas part of the viral syndrome.5,14,31. Here, ACE2 is linked to Encephalopathy.