In this study, our data showed that NSCLC cells with acquired EGFR TKI resistance are more tolerant to low glucose-induced autophagy following a metabolic shift to higher glucose uptake and glycolysis activity due to upregulation of active glucose transporter SGLT1 by Thr678-phosphorylated EGFR, in a PKCδ-dependent manner. Here, SLC5A1 is linked to non-small cell lung carcinoma.