To examine whether SGLT1 also plays a role in conferring intrinsic resistance to EGFR TKIs, the experimental metastatic NSCLC xenograft model was established by tail vein injection of SGLT1-positive and TKI-insensitive A549 cells transfected with the luciferase gene. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.