Although the EGF-activated PI3K/Akt/CREB signaling axis upregulates SGLT1 expression and enhances glucose uptake in intestine epithelial cells [62], the tyrosine kinase activity of EGFR or IGF1R and Akt signals are not needed for SGLT1 upregulation in cancer cells [46, 63]. Here, IGF1R is linked to cancer.