Interestingly, PKCδ S643/676 phosphorylation, which is mediated by mTORC2, but not T505 phosphorylation, was observed in the H322/ER and HCC827/ER clones (Fig. 7j and Supplementary Fig. S8i) and in the xenograft tumor tissues of parental H292 cells after 1 month of erlotinib treatment (Fig. 7k). Here, PRKCD is linked to neoplasm.