SLC5A2 and breast carcinoma: Although SGLT2, typically expressed in the renal proximal tubule, has also been reported to play a critical role in the development of pancreatic or breast cancer [60, 61], our data showed that SGLT1, but not SGLT2, is upregulated in response to EGFR TKI treatment, which supports glucose uptake and cellular viability in NSCLC cells with acquired TKI resistance.