EGFR and neoplasm: The upregulation of EGFR T678 phosphorylation was also observed in the xenograft tumor tissue of parental H292 cells after 1 month of erlotinib treatment (Fig. 7b), in the xenograft tissues of H292/ER clones (Supplementary Fig. S8b), and in human NSCLC tumors with acquired TKI resistance (Fig. 7c), compared with their parental counterparts.