In the liver, YAP activation not only induces transdifferentiation of hepatocytes into ADCs, but also promotes the development of hepatocellular carcinomas (HCC), cholangiomas and intrahepatic cholangiocarcinomas (iCCA)58–61, which prompted us to explore the role of Fascin1 in liver tumorigenesis. Here, YAP1 is linked to intrahepatic cholangiocarcinoma.