SIRT2 inhibition with SirReal2 significantly slowed tumor progression in WT mice (Fig. 6b, P  < 0.0001 on Days 17 and 19; Fig. 6c, P  = 0.0002), but had no effect on melanoma tumor progression in SIRT2 deficient Sirt2-KO mice. Here, SIRT2 is linked to melanoma.