To determine whether systemic SIRT2 expression plays a role, we examined allograft melanoma tumor progression in genetic murine models in which SIRT2 was expressed normally in wild-type (WT) mice and overexpressed in transgenic Sirt2-knockin (Sirt2-KI) mice that contain 3 copies of the Sirt2 gene28. This evidence concerns the gene SIRT2 and neoplasm.