EIF2AK2 and hydrops fetalis: Next we checked the protein and mRNA levels of PKR in skeletal muscle, liver, pancreas and adipose tissue and found that PKR was significantly upregulated in the HF + STZ rats, whereas this upregulation was significantly attenuated in the HF + STZ + IHZ rats, indicating that IHZ is effectively blocking HF + STZ induced PKR upregulation (Fig. 2).