As a marker for differentiating pleural effusion in MPM, SLPI is described only in a report by Blanquart et al.16; however, in their report, three markers (CCL2, galectin-3, and SMRP) were reportedly effective, and if they were used properly, MPM could be differentiated from other diseases that cause pleural effusion, with an AUC of 0.968. Here, LGALS3 is linked to Pleural effusion.