SMAD3 and pancreatic adenocarcinoma: Later, using TCGA data, we realized that the expression of PTEN, CREB1, CASP3, and SMAD3 are significantly (|Log FC| ≥ 1 and p value < 0.01 as the cut-off criteria) increased in Pancreatic adenocarcinoma (PAAD) (data not shown).