We also confirmed that mutant ACE2-Fcs effectively neutralized H4-resistant F490V mutated virus, as well as escape mutants from COVID-19 convalescent plasma, Δ69-70/D796H that emerged in the immunosuppressed patient chronically treated with convalescent plasma13 and insertion of N-linked glycan sequence (248aKTRNKSTSRRE248k) from the long-term cell culture experiment12 (Supplementary Fig 10a-c). This evidence concerns the gene ACE2 and COVID-19.