Besides VEGFA, the classic promoter of tumor-associated angiogenesis49, and ANG1/2, which contribute to tumor angiogenesis in conjunction with VEGFA50, we assessed EGF, increasingly recognized as a stimulator of hypoxia-mediated angiogenesis51, and PECAM1/CD31, a read-out for systemic angiogenic activity52,53. The gene discussed is PECAM1; the disease is neoplasm.