In this study, we demonstrate that METTL3 is upregulated in ESCC and enhances m6A of APC mRNA, thereby leading to recruitment of YTHDF for APC mRNA degradation and subsequent enhanced aerobic glycolysis, ESCC cell proliferation, tumour formation in mice and poor prognosis in patients. This evidence concerns the gene METTL3 and esophageal squamous cell carcinoma.