APC and neoplasm: We showed that METTL3 depletion reduced tumour size (Fig. 6e and Supplementary Fig. 7a), volume (Fig. 6f and Supplementary Fig. 7b) and weight (Fig. 6g and Supplementary Fig. 7c), as well as the amount of lactate in the tumour tissue (Supplementary Fig. 7d) were restored by APC depletion.