High-risk and advanced PCas shared the expression of diverse proteins that are reportedly associated with cancer progression, namely TGF-β [79], Wnt5a/b [34, 35, 80], Shc1 (phospho-SHCY317) [28], phospho-c-RAF-S338 and phospho-c-MycT58/S62 [81]. This evidence concerns the gene SHC1 and cancer.