We observed that in SNCATRIP neurons, aggregates triggered by 1 μM of PD-amplified or MSA-amplified fibrils caused loss of neuronal axonal integrity as evidenced by TH (Fig. 3c) or TUJ1 immunostaining (Fig. 3f) and progressively increased nuclear fragmentation (Fig. 3g, h). Here, TH is linked to multiple system atrophy.