Such considerations are of highest interest given the major combinatorial possibilities that may offer together with diverse immunotherapeutic compounds such as those targeting the Programmed cell Death 1 (antiPD-1) and the Programmed cell Death Ligand 1 (antiPD-L1) which directly activate CD8+ susceptibility against tumor cells as well as novel compounds targeting Natural Killer Cells ligands such as NKG2A targeting monalizumab which eventually enhances NK mediated excytotoxicity [133]. Here, CD274 is linked to neoplasm.