IL1B and acquired idiopathic inflammatory myopathy: On the systemic level, over the 24-week intervention in the IG, we did not observe any significant increase in either routine inflammatory biomarkers (CRP and ESR), or selected pro-inflammatory cytokines (IL-1β, IL-6, and TNF) or chemokines (IL-8, and MCP-1) which play a substantial role in the pathophysiology of IIM [1, 3, 30–34] (Table S3).