IMP3 and adenoma: Histological examination of H&E-stained sections found that among the mice bearing colon tumors, the percentages of adenomas, low-grade adenocarcinomas and high-grade adenocarcinomas in AOM/DSS-administered IMP3fl/fl mice were 36%(18/50), 20%(10/50), and 44%(22/50), respectively, whereas the corresponding percentages in AOM/DSS-administered IMP3−/− mice were 71.43%(15/21), 23.81%(5/21) and 4.76(1/21)%, respectively (Fig. 2E,F,G).