In addition, Src and FAK can promote the EMT via disruption of E-cad-dependent cell-cell junctions, and thus enhance tumor cell motility [45, 46].Here, we observed a remarkable decrease of Src and FAK phosphorylation in ZIP13-depleted ovarian cancer cells, and this indicated that ZIP13 may promote ovarian cancer metastasis via Src/FAK signaling pathway. This evidence concerns the gene PTK2 and ovarian cancer.