Interestingly, down-regulated genes associated with “Cell adhesion molecules (CAMs)”, known to play a fundamental role in the metastatization of CRC when down-regulated; “regulation of BMP signaling pathway”, whose inactivation is consolidated in the initiation/progression of gastrointestinal cancers; “Formation of NR-MED1 Coactivator Complex”, often down-regulated in CRC, linked to the WNT/β-catenin signaling cascade, and associated with lymph node metastasis and advanced TNM stage [47–53]. Here, MED1 is linked to colorectal carcinoma.