It should be noted that ~8% (73/952) of DEGs in our primary analysis were excluded from the novel TPM-based approach due to a lack of ENSEMBL-defined one-to-one human-to-mouse ortholog, including preeclampsia associated genes (ERVW-1, KISS1, LGALS13, SIGLEC6) and HPGs (GPC3, INSL4, MAGEA4, NAA11, OLAH, PSKH2) (Additional file 1: Fig. S4D, E). The gene discussed is SIGLEC6; the disease is preeclampsia.