When compared with healthy controls, a meta-analysis found that MBL2 exon 1 polymorphisms were associated with host susceptibility to HIV-1 infection in three genetic models (dominant, recessive and allelic model) (P < 0.05), and the MBL2 0/0 mutant allele has also been previously associated with an increased risk for HIV infection (p < 0.00001) [19]. This evidence concerns the gene MBL2 and HIV-1 infection.