CD4 and infection: A large proportion (4,108/7,443; odds ratio [OR] = 18.35; P < 10−15) of the probes comprising these 20 modules were among the 5,280 probes that detected significant (FDR < 5%) differential expression between IIIB- and mock- or IIIBΔEnv-infected cells in our time point-specific tests, indicating that these 20 modules represent most of the temporal gene expression patterns that are characteristic of the ex vivo CD4+ T-cell response to infection with HIV-1.