HLA-DRB1 and type 1 diabetes mellitus: As there have not been any CD4+ T cell clones or T cell responses restricted to DRB1*04:03 or DRB1*04:07 heterodimers and specific for any T1D autoantigen, we cannot elaborate further on the factors that contribute to T1D resistance by these two β71R/β74E heterodimers.