In the only comparative study of the binding epitopes of (prepro)insulin and GAD65 (the two major T1D autoantigens revealed in age-dependent seroconversion in the TEDDY birth cohort [16,43]) to DRB1*04:01, DRB1*04:03 and DRB1*04:05, the latter molecule was shown to bind very few epitopes with IC50 value < 10 μM from either antigen (epitope distribution: for preproinsulin, 2/2/0 and for GAD65, 21/23/8, respectively) [29]. This evidence concerns the gene INS and type 1 diabetes mellitus.