HLA-DRB1 and type 1 diabetes mellitus: In Swedish T1D children, we determined by next generation targeted sequencing that the HLA-DR4 had four susceptible subtypes HLA-DRB1*04:01, *04:02, *04:04 and *04:05, two T1D protective subtypes HLA-DRB1*04:03 and *04:07, and one neutral subtype HLA-DRB1*04:08[5].