Common and rare genetic variants at the regulators of complement activation locus on chromosome 1, which contains the CFH and CFHR genes, contribute to AMD risk (Cipriani et al., 2020; Edwards et al., 2005; Fritsche et al., 2016; Haines et al., 2005), in addition to a number of genetic variants in the complement factor I (CFI) gene region on chromosome 4 (Alexander et al., 2014; Fagerness et al., 2009). This evidence concerns the gene CFI and age-related macular degeneration.