Sequencing results were used to investigate: (1) an association between rare CFI gene variants and SNPs at the CFI region of chromosome 4, which could suggest linkage disequilibrium; and (2) an association between rare CFI gene variants and complement risk SNPs at common AMD loci that could suggest the influence of overall complotype on FI activity and the alternative complement pathway in GA (Lay et al., 2015). Here, CFI is linked to age-related macular degeneration.