IDH1 and acute myeloid leukemia: (ii) IDH1 and IDH2 mutations were detectable as premalignant, high-risk gene mutations years before the diagnosis of AML, but not in age-matched controls (8%; n = 15/188; three IDH1 R132C/H/G and 12 IDH2 R140 positive individuals with a median of 7 years before AML diagnosis) [26].