Of potential relevance, there was a striking depletion of CD19+ B cells in mice infected with WT and Δisp2:ISP2, while mice infected with Δisp2 had approximately 3-fold higher frequency of those cells (Fig 5J), associating the lack of TbISP2 presumably with protection of the host antibody response over the course of infection. The gene discussed is CD19; the disease is infection.