ESR1 and Familial prostate cancer: For instance, Morinda offcinalis–Lycium barbarum coupled-herbs (MOLBCH) can regulate the PI3K/Akt signaling pathway, prostate cancer, and the AGE-RAGE signaling pathway, regarded as the most representative pathways, by the core potential targets, the androgen receptor (AR), estrogen receptor (ESR1), mitogen-activated protein kinase 3 (MAPK3), RAC-alpha serine/threonine-protein kinase (AKT1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to alleviate apoptosis, promote male reproductive function, and reduce oxidant stress in the treatment of oligoasthenozoospermia [59].