Upregulation of the mitochondrial fusion machinery and in particular gain‐of‐function mutations of Mfn2 associated with Charcot–Marie–Tooth‐2 (CMT2) pathology lead to mitochondrial remodelling and the accumulation of hyperfused “giant mitochondria” in neuronal somas (Santel & Fuller, 2001; El Fissi et al, 2018). This evidence concerns the gene MFN2 and Charcot-Marie-Tooth disease type 2.