Recent landmark sequencing studies have demonstrated gene expression profiles and somatic mutations such as TP53, CDKN2A, PTEN, PIK3CA, EGFR, HRAS, FBXW7 and NOTCH1 in diverse anatomical sites of HNSCC (Agrawal et al.2011; Stransky et al.2011; Pickering et al.2013; The Cancer Genome Atlas Network 2015). This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.