IGF1 and myocardial ischemia: The most highly expressed paracrine factors were TGF-β1, which attenuates myocardial ischemia-reperfusion injury (Chen et al., 2003), IGF-1, which prevents long-term left ventricular remodeling after cardiac injury (Dai and Kloner, 2011; Figure 3F), and MYDGF, which mediates ischemic tissue repair (Korf-Klingebiel et al., 2015; Figure 3F).