Moreover, the application of 5‐Aza‐DCYD methylation inhibitors to upregulate LRP1B expression has been found to partially restore the inhibition of tumor proliferation and migration in multiple malignant tumors, such as oral squamous cell carcinoma,32 esophageal squamous cell carcinoma,33 gastric carcinoma,29 and kidney carcinoma.30 This evidence concerns the gene LRP1B and oral cavity squamous cell carcinoma.