Moreover, the application of 5‐Aza‐DCYD methylation inhibitors to upregulate LRP1B expression has been found to partially restore the inhibition of tumor proliferation and migration in multiple malignant tumors, such as oral squamous cell carcinoma,32 esophageal squamous cell carcinoma,33 gastric carcinoma,29 and kidney carcinoma.30 The gene discussed is LRP1B; the disease is renal carcinoma.