In addition, severe cases of COVID-19 are accompanied with dysregulation of monocyte populations with increased level of S100A8/A9 or calprotectin (Schulte-Schrepping et al., 2020; Silvin et al., 2020), which can prime and induce the inflammasome activation (Goldberg et al., 2017). This evidence concerns the gene S100A8 and COVID-19.