Consistent with the identification of significant genes, protein profiling in breast cancer samples from the HPA using immunohistochemistry showed that the gene expression of CLDN7, RBM33, SH3RF1, and UBE2Z was significantly enriched in breast cancer, whereas there was no significant enrichment of FGF7 and TNRC6B (Figure 4). The gene discussed is CLDN7; the disease is breast cancer.