In the analysis of the correlation between overall survival and significant DEG expression (CLDN7, MLLT10, RBM33, SH3RF1, SSBP4, and UBE2Z) in breast cancer, we found a shorter survival time based on GSE5881 (Figure 6a) and GSE42568 (Figure 6b) (P< 0.05). The gene discussed is CLDN7; the disease is breast cancer.