In this study, we identified 10 significant genes (CLDN7, MLLT10, RBM33, SH3RF1, SSBP4, UBE2Z, BMPER, FGF7, MSRB3, and TNRC6B) in breast cancer using combined GWAS data and profiling of DEGs. Here, MSRB3 is linked to breast carcinoma.