In this study, we identified 10 significant genes (CLDN7, MLLT10, RBM33, SH3RF1, SSBP4, UBE2Z, BMPER, FGF7, MSRB3, and TNRC6B) in breast cancer using combined GWAS data and profiling of DEGs. This evidence concerns the gene SH3RF1 and breast cancer.