We found that 1 mM Bupivacaine signally inhibits CRC cell apoptosis rate, possibly because the drugs we used was at much higher concentration than that by Bundscherer A et al. Bax is a pro-apoptosis protein, which elevates mitochondrial membrane permeability after receiving apoptosis signal, resulting in decreased membrane potential and promoting the release of apoptosis factors to cytokines. This evidence concerns the gene BAX and colorectal carcinoma.