Similarly, regulation of other genes located centromeric to D4Z4 may be also be affected, with mouse models over‐expressing Frg1 (Gabellini et al, 2006), Slc25a4 (Ant1) (preprint: Wang et al, 2020) or null mutations in Fat1 (Caruso et al, 2013) developing muscular dystrophic phenotypes with some similarities to FSHD. Here, FAT1 is linked to Facioscapulohumeral dystrophy.