Similarity in sequence and function of the homeodomains of DUX4 and PAX7 (Bosnakovski et al, 2008; Bosnakovski et al, 2017b), that PAX3/7 can ameliorate the DUX4‐mediated deleterious phenotype in mouse myoblasts (Bosnakovski et al, 2008), and PAX7 being a master regulator of post‐natal myogenesis (Seale et al, 2000), prompted us to further examine the role of PAX7 in FSHD. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.