Thus, of the 4/8 independent muscle datasets that associate raised DUX4 target gene expression with FSHD, all had either MRI or transcriptomic evidence of inflammation and 3/4 were profiled by RNA‐seq, suggesting that both factors contribute to DUX4 target gene detection (Table 1). Here, DUX4 is linked to Facioscapulohumeral dystrophy.