Top‐down examination also shows that PAX7 target gene score repression is a significant biomarker of FSHD status and associated with FSHD muscle cells (Banerji & Zammit, 2019) but not FSHD immune cells (Banerji et al, 2020c) (Fig 4). This evidence concerns the gene PAX7 and facioscapulohumeral muscular dystrophy.