In eight independent FSHD muscle gene expression datasets (totalling 157 FSHD and 98 matched control biopsies), the three “exogenous” DUX4 target gene sets were elevated in only 3/8 datasets (Banerji & Zammit, 2019) (Table 1). Here, DUX4 is linked to Facioscapulohumeral dystrophy.