RNA‐seq at eight morphologically defined time points during FSHD hypotrophic myogenesis identified suppression of mitochondrial biogenesis pathways as prominent, notably peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC1α) and oestrogen‐related receptor A (ERRα). The gene discussed is PPARGC1A; the disease is facioscapulohumeral muscular dystrophy.