The C‐terminal transactivation domain of DUX4 is fused to the CIC gene in ~ 27% of Ewing sarcoma, but without the homeodomains, the CIC‐DUX4 fusion protein cannot activate DUX4 target genes (Kawamura‐Saito et al, 2006). This evidence concerns the gene DUX4 and Ewing sarcoma.