The best discrimination performance was achieved by a model including D-dimers, NT-pro-BNP, and troponin-I (AUC 0.788), whereas a combined model including age, arterial hypertension, coronary artery disease, diabetes mellitus type II, LVEF, RV-function, significant TR, and elevated RV-pressure performed poorly in predicting the combined endpoint (AUC 0.603) (Figure 4). The gene discussed is NPPB; the disease is Hypertension.