PTEN and male reproductive organ cancer: To better understand the impact of age on prostate carcinogenesis, we created a spatially and temporally controlled Pten ablation (Ptenadcre+) in the mouse prostatic epithelium via intraductal delivery of the Cre-expressing adenovirus directly into the APs of Pten-floxed mice at different ages (Leow et al., 2005).