In conclusion, our study identified that m6A regulators play a significant role in the immune microenvironment of 33 TCGA cancer types; meanwhile, it provided a vital insight for revealing the association between m6A regulators and anticancer drug sensitivity, which sheds a novel light on exploring mechanistic and therapeutic targets in the immune microenvironment of 33 cancer types and NSCLC. The gene discussed is METTL3; the disease is cancer.