The higher the METTL14, YTHDC1, ZC3H13, FTO, and YTHDC2 expression level, the fewer the characteristics of tumor LUAD stem cells and higher the tumor LUAD differentiation, while the expression of METTL3, WTAP, RBM15, RBM15B, YTHDF1, YTHDF2, HNRNPC, IGF2BP1, VIRMA, HNRNPA2B1, and IGF2BP3 was positively associated with the LUAD stem cell score (based on RNA expression). The gene discussed is IGF2BP1; the disease is neoplasm.