A phase two, sequentially enrolled, multicohort, multicenter, nonrandomized, open-label research showed that dabrafenib plus trametinib provides a novel therapy with clinically meaningful antitumor activity and a potential safety profile for previous untreated BRAFV600E-mutant NSCLC patients (Planchard et al., 2017).A study has shown that YES1 acts as a predictive biomarker promotes the proliferation and progression of lung cancer and provides support for the clinical evaluation of dasatinib treatment (Garmendia et al., 2019). This evidence concerns the gene YES1 and lung cancer.