We detected a significant association between YAP1 expression and markers of total T cells (CD3E and CD2), CD8+ T (CD8A and CD8B), TAMs (CD68 and IL10), monocytes (CD86 and CD115), M1 macrophages (INOS, IRF5, and COX2), M2 macrophages (CD163, VSIG4, and MS4A4A), NK cells (KIR2DL4), neutrophils (CD11b), DCs (HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRA, HLA-DRA1, BDCA-4, and CD11C), Tfh (BCL6), Th1 (STAT1 and IFN-γ), Th2 (GATA3, STAT6, and STAT5A), Th17 (STAT3), and Tregs (FOXP3, CCR8, STAT5B, and TGFβ1) in PAAD (Table 2). This evidence concerns the gene IRF5 and pancreatic adenocarcinoma.