CYP2R1 and obesity due to melanocortin 4 receptor deficiency: Additionally, we applied adjustment for obesity in multivariate logistic regression models, showing that DHCR7/NADSYN1 rs12785878 and CYP2R1 rs10741657 variants remained significant predictors of severe COVID-19 in adults (OR 0.22, 95% CI 0.06-0.93, p= 0.02; OR 4.9, 95% CI 1.5-16.4, p= 0.009, respectively).