UCHL1 and major depressive disorder: The current animal study was designed to “treat” TBI-related symptoms, including depression and/or anxiety with a combination of EPA and DHA, and the AIDM juice provided post-injury contained equal amounts of EPA:DHA, with the manufacturer also willing to provide a placebo juice without the supplemental omega-3 and vitamin D. However, with minimal uptake of EPA into neuronal tissues (Table 1), the significantly altered profiles of plasma T-tau, GFAP and UCH-L1 post-TBI cannot be attributed to the dietary EPA in this model.